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¿µ¾î¸¦ Á» ÀßÇÏ´Â ÆíÀ̶ó°í?

ÑÑçµÑû(Á¶°©Á¦´åÄÄ)

Á¶±¹ Èĺ¸ÀÚÀÇ µþÀÌ ÇÑ¿µ¿Ü°í ½ÃÀý 2ÁÖ°£ ÀÎÅÏÀ¸·Î Âü¿©ÇØ Á¦1ÀúÀÚ·Î µîÀçµÈ ³í¹®À» Á¶±Ý ¹ø¿ªÇغôÙ.
³»¿ëÀÌ ¾î·Á¿î °ÍÀº µÑ°ġ°í ¿ÀÅ»ÀÚ¿Í ¾î»öÇÑ Ç¥ÇöÀÌ ¸¹ÀÌ ³ª¿Â´Ù. Á¶±¹Àº ³í¹® Á¦1ÀúÀÚ ³í¶õ°ú °ü·Ã,
¡°¿ì¸® ¾ÆÀÌ°¡ ¿µ¾î¸¦ Á» ÀßÇÏ´Â Æí¡±À̶ó¸ç ¡°¿¬±¸ ¼º°ú¸¦ ¿µ¾î·Î Á¤¸®ÇÏ´Â µ¥ Å« ±â¿©¸¦ Çß´Ù°í Æò°¡ÇÑ
°Í °°´Ù¡±°í Çß´Ù. ±×·¡¼­ ³í¹®À» Àо °ÍÀε¥, ³í¹®¿¡¼­ °¡Àå Áß¿äÇÏ´Ù°í ÇÒ ¼ö ÀÖ´Â ÃÊ·Ï(abstract)
ÀÇ Ã¹ ¹®ÀåºÎÅÍ ¿ÀŸ°¡ ³ª¿Ô´Ù.

ÃÊ·ÏÀÇ Ã¹ ¹®ÀåÀº ´ÙÀ½°ú °°´Ù.

Background : In perinatal hypoxic-ischemic encephalopathy (HIE), cerebral blood flow is
impaired and the activity of nitric oxide systhase (NOS) is markedly increased.

ÀÏ»êÈ­Áú¼Ò ÇÕ¼ºÈ¿¼Ò¸¦ ¶æÇÏ´Â nitric oxide systhase (NOS)¸¦ ½è´Âµ¥ systhase°¡ ¾Æ´Ï¶ó synthase
ÀÌ´Ù.

ÃÊ·Ï¿¡´Â ¹®¹ýÀû ¿À·ù°¡ ¿©·µ ½Ç·Á ÀÖ´Ù. °á°ú¸¦ ¼³¸íÇÏ´Â ºÎºÐ¿¡´Â ´ÙÀ½°ú °°Àº ¹®ÀåÀÌ ÀÖ´Ù. ¡°The
comparisons between the controls and each subgroups¡¦¡± ¸¶Áö¸· ºÎºÐ¿¡ each°¡ ³ª¿À´Âµ¥ each
´ÙÀ½¿¡´Â Ç×»ó ´Ü¼ö ¸í»ç°¡ µû¶ó¿Í¾ß ÇÑ´Ù. Subgroups°¡ ¾Æ´Ï¶ó subgroupÀ̾î¾ß ÇÑ´Ù. º¹¼öÇüÀÎ
subgroups¸¦ ±»ÀÌ ¾²°í ½ÍÀ¸¸é each of°¡ ¾Õ¿¡ ÀÖ¾î¾ß ÇÑ´Ù.

For the association with the development of a strokeÀ̶ó´Â Ç¥Çöµµ ³ª¿À´Âµ¥ ³úÁ¹ÁßÀ» ¶æÇÏ´Â
stroke ¾Õ¿¡ ´Ü¼ö¸¦ »ó¡ÇÏ´Â a´Â ÇÊ¿ä ¾ø´Ù. ÀÌ·¸°Ô ÀϹÝÀûÀ¸·Î »ç¿ëÇÒ ¶§´Â a ¾ø´Â strokes°¡ ¸Â´Â
´Ù.

³í¹®ÀÇ Ã¹ ÆäÀÌÁö¸¦ ¹ø¿ªÇغôÙ. °³ÀÎÀûÀ¸·Î´Â ¿µ¾î·Îµµ ÀÌÇØ°¡ ¾ÈµÇ°í Çѱ¹¾î·Îµµ ÀÌÇØ°¡ ¾ÈµÆ´Ù. ±×
¸¸Å­ Àü¹®ÀûÀÎ ³»¿ëÀÌ´Ù. º»ÀÎÀÌ ¹ø¿ªÇÑ ºÎºÐ°ú ¿µ¹®À» ÇÔ²² ¼Ò°³ÇÑ´Ù.


<¹è°æ: Ãâ»ê ÀüÈÄÀÇ ÇãÇ÷¼º Àú»ê¼Ò³úº´Áõ(HIE) »óȲ¿¡¼­ ´ë³úÀÇ Ç÷·ù´Â ¼Õ»óµÇ°í ÀÏ»êÈ­Áú¼Ò ÇÕ¼ºÈ¿
¼Ò´Â Å©°Ô Áõ°¡Çß´Ù. ³úÁ¹ÁßÀ¸·Î ÁøÇàµÇ´Â °Í°ú °ü·Ã, ÀÏ»êÈ­Áú¼ÒÇÕ¼ºÀÇ ´ÙÇü(Òýúþ)Àº Àß ¾Ë·ÁÁ® ÀÖ´Ù.
¹æ¹ý: 37¸íÀÇ HIE ȯ¾Æ¿Í 54¸íÀÇ Á¤»ó ½Å»ý¾ÆÀÇ Á¦ÇÑ È¿¼Ò ¼ÒÈ­¸¦ ÅëÇϰųª ÅëÇÏÁö ¾ÊÀº Æú¸®¸Þ¶ó¾ÆÁ¦
¿¬¼â ¹ÝÀÀÀ» ºÐ¼®, ¼¼ °¡ÁöÀÇ ÀÓ»óÀûÀÎ ´ÙÇüÀÌ ³ªÅ¸³µ´Ù. À¯ÀüÀÚÇü°ú ´ë¸³ ÇüÁú, ÀϹèüÇü(ìéÛÃô÷úþ)ÀÇ
Áֱ⿡ ´ëÇÑ Â÷ÀÌÁ¡Àº Á¶»çÀÚ ±×·ìÀ» ³ª´©¾î Æò°¡µÆ´Ù.
°á°ú: ´ë¸³ ÇüÁú Áֱ⸦ ºÐ¼®ÇÑ °á°ú ÅëÁ¦Áý´Üº¸´Ù HIE Áý´Ü¿¡¼­ Glu298ASPÀÇ G ´ë¸³ ÇüÁúÀÌ ´õ¿í ÀÚ
ÁÖ ÀÖ´Â °ÍÀ» º¼ ¼ö ÀÖ´Ù. HIE¿Í °ü·ÃÇÑ ºñ±³ Áý´Ü ¹× °¢Á¾ ¼¼ºÎ Áý´ÜÀ» ºñ±³ÇÑ °á°ú, ´Ù¸¥ ºñ±³Áý´Üº¸
´Ù ½Å»ý¾ÆÀÇ Æó°íÇ÷¾Ð(PPHN) ȯÀÚ¿¡¼­ TC À¯ÀüÀÚÇü°ú T-786CÀÇ C ´ë¸³ ÇüÁúÀÌ ´õ¿í ¸¹ÀÌ ¹ß°ßµÆ´Ù.
HIE ȯÀÚÀÇ °æ¿ì ´Ù¸¥ Áý´Ü°ú ºñ±³ÇßÀ» ¶§ A b T ÀϹèüÇü Áֱ⸦ º¸ÀÌ´Â °ÍÀÌ Àû¾ú´Ù.
°á·Ð: Glu298AspÀÇ G ´ë¸³ ÇüÁúÀº Ãâ»ê ÀüÈÄÀÇ HIE¿Í °ü°è°¡ ÀÖ°í TC À¯ÀüÀÚÇü°ú T-786CÀÇ C ´ë¸³
ÇüÁúÀº ½Å»ý¾ÆÀÇ Æó°íÇ÷¾Ð°ú °ü°è°¡ ÀÖ´Ù.

(º»¹®)
»êÈ­Áú¼Ò(NO)´Â ÀÏ»êÈ­Áú¼ÒÇÕ¼ºÈ¿¼Ò¸¦ ÅëÇØ L-¾Æ¸£Áö´ÑÀÌ L-½ÃÆ®·ê¸°À¸·Î »êÈ­µÇ´Â °úÁ¤¿¡¼­ ¹ß»ý
ÇÑ´Ù. ³»ÇǼ¼Æ÷´Â Ç÷°ü±äÀåµµ¸¦ °ü¸®ÇÏ´Â Áß¿äÇÑ »ý¸®Àû ¿ªÇÒÀ» ÇÏ´Â ³»ÇÇÀÇ ÀÏ»êÈ­Áú¼ÒÇÕ¼ºÀ» ÅëÇØ
»êÈ­Áú¼Ò¸¦ ¸¸µé ¼ö ÀÖ´Ù. ¾Æ¿ï·¯, »êÈ­Áú¼Ò´Â ºÎµå·¯¿î ±ÙÀ°¼¼Æ÷ÀÇ È®»êÀ» Á¶ÀýÇÏ°í ³»ÇÇ¿¡ »ý±â´Â ¹é
Ç÷±¸Á¢ÇÕÀ» Èñ¼®½ÃÅ°°í, Ç÷¼ÒÆÇÀÀÁýÀ» ¾ïÁ¦ÇÑ´Ù.

Background : In perinatal hypoxic-ischemic encephalopathy (HIE), cerebral blood flow is
impaired and the activity of nitric oxide systhase (NOS) is markedly increased. For the
association with the development of a stroke, the endothelial NOS (eNOS) polymorphisms are
well-known. Methods : Three clinically relevant polymorphisms of the eNOS gene were
determined in 37 term/near-term infants with perinatal HIE (HIE group) and 54 normal term
newborn infants without any perinatal problems (control group) using a polymerase chain
reaction with or without restriction fragment enzyme digestion. The differences in the genotype,
allele, and haplotype frequencies were evaluated between the groups. Results : The analysis of
the allele frequencies showed that the G allele of Glu298Asp was more frequent in the HIE group
than in the controls. The comparisons between the controls and each subgroups with
complications that occurred with HIE showed that the TC genotype and C allele of T-786C were
more common in patients with persistent pulmonary hypertension of the newborn (PPHN) than
in the controls. The frequency of the A b T haplotype was lower in the HIE patients than in the
controls. Conclusions : The G allele of Glu298Asp was associated with perinatal HIE, while the
TC genotype and C allele of T-786C were associated with PPHN.

Nitric oxide (NO) is produced from the oxidation of L-arginine to L-citrulline by NO synthase
(NOS).1 Endothelial cells are able to produce NO via endothelial NOS (eNOS), which has an
important physiologic role in regulating vascular tone. Moreover, NO modulates smooth muscle
cell proliferation and attenuates leukocyte adhesion to the endothelium, as well as inhibition of
platelet aggregation.



[ 2019-09-04, 11:13 ] Æ®À§ÅÍÆ®À§ÅÍ ÆäÀ̽ººÏÆäÀ̽ººÏ ³×À̹ö³×À̹ö

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